Draw and label a diagram to illustrate the molecular structure of a desmosome

1. The desmosome.
Answer all parts of this question:
a) Draw and label a diagram to illustrate the molecular structure of a desmosome.
(5 marks)
b) Briefly describe the function of a desmosome. (4 marks)
c) List the major desmosomal cadherins and their subtypes. (2 marks)
d) Briefly discuss the proposed pathomechanism of blister/pustule formation in the
pemphigus complex. (5 marks)
e) Briefly discuss the evidence supporting the current understanding of the target
autoantigen/s of canine pemphigus foliaceus (PF) (8 marks). Compare this with
the autoantigen/s of human PF (1 mark).
f) Name the target autoantigen/s in pemphigus vulgaris (1 mark). Briefly describe
the correlation between the location of the autoantigen and the clinical and
histopathologic disease (2 marks).
g) List the target autoantigens reported in canine paraneoplastic pemphigus.
(2 marks)
Section C continued over page
Veterinary Dermatology Paper 1 Page 8 of 8
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
2. Collagen.
Answer all parts of this question:
a) Describe the structure of collagen 1 (a labelled diagram is acceptable).
(3 marks)
b) List the key post-translational steps in the synthesis of collagen 1. Include the
stages that occur in the intracellular (10 marks) and the extracellular
space (5 marks).
c) Briefly describe four (4) molecular mechanisms that regulate collagen
homeostasis in normal skin. (4 marks)
d) Briefly describe the abnormality in collagen synthesis in the following clinical
i. scurvy (2 marks)
ii. dermal atrophy following glucocorticoid administration (2 marks)
iii. dermatosparaxis in cattle (2 marks)
iv. hereditary equine regional dermal asthenia (HERDA). (2 marks)
3. Answer all parts of this question:
a) Discuss the genetic aspects of antimicrobial resistance to Staphylococcus
pseudintermedius; in your answer discuss the mechanisms that confer increased
resistance to tetracycline, beta-lactam and fluoroquinolone antibiotics.
(10 marks)
b) Discuss the stages of biofilm formation and five (5) mechanisms of a biofilm
that confer increased antimicrobial resistance. (10 marks)
c) Describe and discuss the bacterial microbiome that has been identified on the
dog using culture-dependent techniques. Your answer should include how this
varies in normal and atopic individuals (8 marks). Briefly contrast this with the
bacterial microbiome identified with culture-independent techniques (2 marks)


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